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姓名：孙晓 职称：教授、博士生导师 办公电话：15064071363 电子邮箱： chebiosx@126.com 主要办公地址：山东省济南市槐荫区青岛路山东第一医科大学科创中心 邮编：250000
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一、简介
孙晓，校拔尖人才，山东省海外优青，泰山学者青年专家，在我校于金明院士放射免疫与分子影像平台的支持下，已开展大量MRI分子影像相关的基础研究工作。目前已主持3项国家级项目（国自然面上项目、国家外专项目、国自然青年项目）、6项省部级项目（泰山学者青年专家项目、山东省海外优青等），主持济南市“高端外专集聚工程”；参与于金明院士临床-基础创新团队项目（基础PI）；以第一/通讯作者在ACS Nano (4篇), Advanced Science (2篇), Advanced Functional Materials (3篇), Bioactive Materials (3篇), Biomaterials (2篇), Coordination Chemistry Reviews (2篇)等国际权威杂志发表系列SCI论文（IF>10论文32篇），总IF>500；已授权国家发明专利16项；获英国皇家化学会生物材料科学“新锐科学家”，获于金明科技创新奖、山东省材料科技奖一等奖、山东省医学科技奖三等奖等奖项；担任山东省多模态影像人工智能遗传学重点实验室副主任，担任BMEMat等7个期刊青年编委及山东省健康管理协会泛血管影像医学分会副主委等职务。
二、研究方向
医学影像探针、纳米药物、生物医用材料等
三、主持/参与的科研项目
[1]国家自然科学基金面上项目，82372031。主持
[2]国家外专项目，Y20240164。主持
[3]国家自然科学基金青年项目，22104073。主持
[4]山东省优青（海外）项目，2022HWYQ-079。主持
[5]泰山学者青年专家项目，tsqn202408248。主持
[6]山东省高校“青创科技计划”，2021KJ100。主持
[7]山东省自然科学基金青年项目，ZR2021QB119。主持
[8]齐鲁卫生与健康杰出青年人才培育工程。主持
[9]山东省海外科技人才项目。主持
[10]济南市“高端外专集聚工程”。 主持
[11] 山东第一医科大学青峰计划。主持
[12]肿瘤放射治疗临床-基础联合创新团队项目（1000万），基础PI之一
[13] 2025年度新兴战略领域研究培养计划项目（1000万），基础PI之一
[14]优势特色临床-基础多学科交叉专项（200万），基础PI
[15]山东省重点研发计划（国际科技合作）（100万），参与
[16]山东第一医科大学附属肿瘤医院学科集群创新工程（300万），参与
四、发表论文情况
1. H. Liu, Y. Yang, N. Zhang,Y. Hou, Z. Zhang, X. Yu, Y. Huang, B. Yan, H. Zhou, M. Mu, Y. Gao, K. Guo, M. Yang*, X. Sun*. Overcoming Photothermal Resistance of Gastric Cancer by Bionic 2D lron-Based Nanoplatform with Precise CRlSPR/Cas9 Delivery. ACS Nano, 2025, 19, 18188−18202. (IF=16.0)
2. G. Ma#, X. Zhang#, K. Zhao#, S. Zhang, K. Ren, M. Mu, C. Wang, X. Wang, H. Liu*, J. Dong*, X. Sun*. Polydopamine nanostructure-enhanced water interaction with pH-responsive manganese sulfide nanoclusters for tumor magnetic resonance contrast enhancement and synergistic ferroptosis-photothermal therapy. ACS Nano, 2024, 18, 4, 3369-3381. (IF=16）
3. X. Sun, Y. Gong, H. Ge, G. Ma, T. Yang, M. Mu, L. Zhang, C. Wang, B. Shen, X. Dai, Z. Wu, X. Zhang*, Q. Fan*, H. Sun*. A novel magnetic resonance nanoprobe for visualizingtumor PD-L1 level and enhancing synergistic radio-immunotherapy. ACS Nano, 2025, Accept. (IF=16.0)
4. X. Sun#, R. Du#, L. Zhang#, G. Zhang, X. Zheng, J. Qian, X. Tian, J. Zhou, J. He, Y. Wang, Y. Wu, K. Zhong, D. Cai*, D. Zou*, Z. Wu*. A pH-responsive yolk-like nanoplatform for tumor targeted dual-mode magnetic resonance imaging and chemotherapy. ACS Nano, 2017, 11, 7049-7059.（IF=16.0）
5. Nengyi Ni, Kuoran Xing, et al., Jianping Xie*, Xiao Sun*, Jinping Wang*, David Leong*. Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy. Advanced Materials, 2025, Minor Revision. (IF=26)
6. Mengyao Mu, Mengmeng Zhang, Jie Liu, Ke Ren, Hui Liu, Lixian Yip, Kai Guo, Feifei Teng, Jian Dong, Xueli Xu*, David Tai Leong*, Xiao Sun*. Real-time magnetic resonance visualization of tumor acidosis as a precognition indicator of therapeutic efficacy. Bioactive Materials, 2025, 52, 63-72. (IF=20.3)
7. X. Xu#, S. Xu#, J. Wan#, D. Wang, X. Pang, Y. Gao, N. Ni, D. Chen*, X. Sun*. Disturbing Cytoskeleton by Engineered Nanomaterials for Enhanced Cancer Therapeutics. Bioactive Materials, 2023, 29, 50–71. (IF=20.3)
8. Y. Gao, M. Mu, Y. Wei, B. Yan, H. Liu, K. Guo*, M. Zhang, X. Dai, X. Sun*, D. T. Leong*. Novel Ultrathin Ferrous Sulfide Nanosheets: Towards Replacing Black Phosphorus in Anticancer Nanotheranostics. Bioactive Materials. 2025, 43, 564-578. (IF=20.3)
9. Mengmeng Zhang, Xinyu Zhang, Chenyu Wang, Mengyao Mu, Ke Ren, Nengyi Ni, Li Xian Yip, Kai Guo, Xiaoyu Hu, Feifei Teng, David Tai Leong, Qing Fan,*, Xiao Sun*. Convertible ROS Nanocatalyst/Eliminator for Enhancing Tumor Radio-Immunotherapy and Relieving Radiation Enteritis. Advanced Science, 2025, e03602. (IF=14.1)
10. H. Liu, X. Dai, N. Li, L. Zhang, Z. Wang, K. Ren, Y. Li,* J. Wan*, X. Sun,* . Injectable Magnetic Hydrogel Incorporated with Anti-inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis. Advanced Science, 2024, 2409778. (IF=14.1)
11. H. Zhou, X. Zhang, H. Liu, Y. Gao, M. Mu, Y. Tang*, T. Jiang, Z. Zhang, S. Liu, L. X. Yip, X. Sun*, Z. Liu*. Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response. Advanced Functional Materials, 2025. (IF=19)
12. J. Cui#, G. Wang#, L.X. Yip#, M. Dong, M. Mu, L. Tian, Y. Gao, Q. Fan, Q. Zhu, X. Zhao*, X. Xu*, D. T. Leong*, X. Sun*. Enhanced ferritin-manganese interaction by nanoplatinum growth enabling liver fibrosis three-dimensional magnetic resonance visualization and synergistic therapy with real-time monitoring. Advanced Functional Materials. 2024, 2410748. (IF=19)
13. H. Liu, M. Mu, Y. Hou, Y. Gong, C. Wang, G. Ma, K. Guo, L. Ma*, X. Sun*. A Novel CRISPR/Cas9-Encapsulated Biomimetic Manganese Sulfide Nanourchins for Targeted Magnetic Resonance Contrast Enhancement and Self-Enhanced Chemodynamics-Gene-Immune Synergistic Tumor Therapy. Advanced Functional Materials, 2024, 202401370. (IF=19)
14. N. Ni, X. Zhang, Y. Ma, J. Yuan, D. Wang, G. Ma, J. Dong*, X. Sun*. Biodegradable Two-Dimensional Nanomaterials for Cancer Theranostics. Coordination Chemistry Reviews, 2022, 458, 214415. (IF=24.833）
15. J. Liu, M. Huang, X. Zhang, Z. Hua, Z. Feng, Y. Dong, T. Sun*, X. Sun*, C. Chen*. Polyoxometalate Nanomaterials for Enhanced Reactive Oxygen Species Theranostics. Coordination Chemistry Reviews, 2022, 472，214785. (IF=24.833）
16. J. Cui#, S. Zhang#, X. Xu#, K. Ren, M. Dong, Z. Nie, Y. Xu, X. Dai, P. Xu, S. Sun, X. Zhao*, X. Sun*. Recent advances of nanomaterials in imaging liver fibrosis. BMEMat. 2025, 3: e12123. (IF =15.5, Back Cover)
17. Zhao et al, Xiao Sun*. ACS Nano, 2025, Major Revision.
18. K.R. Xing et al, Xiao Sun*, David Leong.* Cell, 2025, Under Review.
19. N. Ni, W. Wang, Y. Sun, X. Sun*, D. T. Leong*. Inducible endothelial leakiness in nanotherapeutic applications. Biomaterials, 2022, 287, 121640. (IF=15.304）
20. X. Sun#, G. Zhang#, R. Du#, R. Xu, D. Zhu, J. Qian, G. Bai, C. Yang, Z. Zhang, X. Zhang, D. Zou*, Z. Wu*. A Biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode MR imaging guided combinatorial cancer therapy. Biomaterials, 2019, 194, 151-160.（IF=15.304）
21. H. Zhou, H. Liu, M. Mu, S. Liu, Y. Gao, K. Guo, M. Zhang, N. Ni, F. Teng, Y. Tang, H. Sun,* D. Chen,* X. Sun*. Photothermal-Triggered Radical Storm for Achieving Multi-Layered PD-Ll Inhibition in Cancer Theranostics. Chemical Engineering Journal, 2025, 513, 162636. (IF=13.2)
22. X. Zhang, H. Liu, C. Wang, Y. Gao, S. Zhao, M. Mu, K. Ren, Y. Gong, Q. Fan*, X. Sun*. Dimeric PD-L1 Specific Affibody Grafted Fe-Based Nanosheets for Tumor-Targeting Dual-Mode Magnet Resonance Imaging and Enhancement of Photothermal-Immunotherapy. Chemical Engineering Journal, 2025, 159400. (IF=13.2)
23. K. Guo, H. Liu, M. Zhang, N.Ni, M. Mu, K. Ren, J. Chen, Q. Fan, X. Xu, X. Sun*, X. Wang*. Overcoming radiation-induced PD-L1 upregulation by novel gadolinium-palladium nanoplatforms for enhanced tumor radio-immunotherapy. Chemical Engineering Journal, 2025, 504, 158754. (IF=13.2)
24. M. Mu , M. Zhang, Y. Gong, K. Guo, H. Liu, Z. Zhang, T. Jiang, H. Zhou, Q. Fan, D. Jia*, Y. Li*, X. Sun*, A multifunctional nanoplatform capable of dual action on tumor PD-L1 for enhanced cancer theranostics. Chemical Engineering Journal, 2024, 502, 158139. (IF=13.2)
25. Chenyu Wang, Wei Tian, Xiaohui Dai, Jupeng Yuan, Nengyi Ni, Qing Fan, Hui Liu, Hongzan Sun*, Jipeng Wan*, Xiao Sun*. Calcium ascorbate loaded ultrathin ferrous sulfide nanosheets thermo-sensitive hydrogels for near-infrared light activation of synergistic endometriosis therapy. Chemical Engineering Journal, 2024, 496, 153740. (IF=15.1)
26. X. Zhang, H. Ge, Y. Ma, L. Song, Y. Ma, G. Tian, L. Wang, Q. Meng*, X. Sun*. Engineered Anti-cancer Nanomedicine for Synergistic Ferroptosis-Immunotherapy. Chemical Engineering Journal, 2023, 455, 140688. (IF=16.744)
27. X. Sun#, M. Zhang#, R. Du#, X. Zheng, C. Tang, Y. Wu, J. He, W. Huang, Y. Wang, Z. Zhang, X. Han, J. Qian, K. Zhong, X. Tian, L. Wu, G. Zhang, Z. Wu*, D. Zou*. A polyethyleneimine-driven self-assembled nanoplatform for fluorescence and MR dual-mode imaging guided cancer chemotherapy. Chemical Engineering Journal, 2018, 350, 69-78.（IF=16.744）
28. X. Sun*, N. Ni, Y. Ma, Y. Wang, D. T. Leong*. Retooling Cancer Nanotherapeutics' Entry into Tumors to Alleviate Tumoral Hypoxia. Small, 2020, 16, 2003000.（IF=15.153）
29. S. Liu, L. Tian, M. Mu, Z. Liu, M. Dong, Y. Gong, X. Wang, H. Zhang*, Q. Meng*, X. Sun*. Platinum Nanoparticles-Enhanced Ferritin-Mn2+ Interaction for Magnetic Resonance Contrast Enhancement and Efficient Tumor Photothermal Therapy, Advanced Healthcare Materials, 2024, 2303939. (IF=10)
30. Y. Gong#, K. Guo#, S. Cai, K. Ren, L. Tian, Y. Wang, M. Mu, Q. Meng*, J. Liu*, X. Sun*. Customized Sized Manganese Sulfide Nanospheres as Efficient T1 MRI Contrast Agents for Enhanced Tumor Theranostics. Biomaterials Research, 2024, 28, 0116. (IF=11.6)
31. W. Tian, C. Wang, R. Chu, H. Ge, X. Sun*, M. Li*. Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic therapy. Biomaterials Research, 2023, 27, 100. (IF=15.863)
32. Y. Gao, S. Liu, H. Liu, H. Ge, M. Zhang, C. Zhao, Y. Gong, X. Zhang, C. Wang*, X. Sun*, Z. Wu*. Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine. Science China Chemistry, 2023, 66, 2492-2512. (IF=9.6)
33. X. Zhang, X. Xu, H. Liu, N. Ni, S. Liu, Y. Gong, G. Ma, L. Song, Q. Fan*, Q. Meng*, X. Sun*. CCR2-overexpressing Biomimetic Carrier-free Nanoplatform for Enhanced Cascade Ferroptosis Tumor Therapy. Acta Biomaterialia, 2023, 166, 604-614. (IF=10.633)
34. X. Xu, A. Liu, S. Liu, Y. Ma, X. Zhang, M. Zhang, J. Zhao, S. Sun, X. Sun*. Application of Molecular Dynamics Simulation in Self-assembled Cancer Nanomedicine. Biomaterials Research, 2023, 27, 39. (IF=15.863)
35. S. Xu, X. Pang, X. Zhang, Q. Lv, M. Zhang, J. Wang, N. Ni, X. Sun*. Nanomaterials disrupting cell-cell junctions towards various diseases. Nano Research, 2023, 16, 7053–7074. (IF=10.263)
36. H. Zhang, M. Zhang, X. Zhang, Y. Gao, Y. Ma, H. Chen, J. Wan, C. Li, F. Wang*, X. Sun*. Enhanced postoperative cancer therapy by iron-based hydrogels. Biomaterials Research, 2022, 26, 19. (IF=15.863）
