一、简介

孙晓，教授，博导，山东省优青，泰山学者青年专家，齐鲁卫生与健康杰出人才，山东省海外科技人才，山东省创新团队带头人，国自然通讯评审专家。曾在中国科学技术大学、中科院合肥物质科学院进行直博学习和研究，此后赴新加坡国立大学开展博士后研究。2020年起在山东省肿瘤医院于金明院士放射免疫与分子影像平台学习。2021年加入山东第一医科大学，主要从事疾病纳米诊疗体系开发等方面研究，相关研究成果以通讯作者在国际权威杂志发表SCI论文40余篇，IF>10有20余篇，授权国家发明专利13项，转化1项；主持国家级课题（外专、面上、青年）3项、省级课题6项；获于金明科技创新奖、山东省材料科技奖一等奖、山东省医学科技奖三等奖、山东省医学会青年科技奖三等奖等奖励。担任BMEMat等期刊青年编委及Advanced Functional Materials、ACS Nano、Bioactive Materials、Nano Letters、Biomaterials等杂志审稿人。讲授《物理化学》、《生物医用材料》等课程。

二、研究方向

医学影像探针、纳米药物、生物医用材料等

三、承担的主要科研/教改项目

1、国家外专项目，2025.01-2026.12，主持

2、国家自然科学基金面上项目，2024.01-2027.12，主持

3、国家自然科学基金青年项目，2022.01-2024.12，主持

4、泰山学者青年专家项目，2025.1-2027.12，主持

5、山东省优青项目，2022.05-2025.04，主持

6、山东省高校青创科技计划，2022.01-2024.12，主持

7、山东省自然科学基金青年项目，2022.01-2024.12，主持

8、齐鲁卫生与健康杰出人才培育工程，2021.01-2025.12，主持

9、山东省海外科技人才项目，2022.01-2024.12，主持

四、近3年IF>10的通讯作者文章

1. Y. Gao, M. Mu, Y. Wei, B. Yan, H. Liu, K. Guo, M. Zhang, X. Dai, X. Sun*, D.T. Leong*. Novel Ultrathin Ferrous Sulfide Nanosheets: Towards Replacing Black Phosphorus in Anticancer Nanotheranostics. Bioactive Materials, 2025, 43, 564-578. (IF=18.9)

2. X. Zhang, H. Liu, C. Wang, Y. Gao, S. Zhao, M. Mu, K. Ren, Y. Gong, Q. Fan*, X. Sun*. Dimeric PD-L1 Specific Affibody Grafted Fe-Based Nanosheets for Tumor-Targeting Dual-Mode Magnet Resonance Imaging and Enhancement of Photothermal-Immunotherapy. Chemical Engineering Journal, 2025, 159400. (IF=15.1)

3. Kai Guo, Hui Liu, Mengmeng Zhang, Nengyi Ni, Mengyao Mu, Ke Ren, Jiahui Chen, Qing Fan, Xueli Xu, Xiao Sun*, Ximing Wang*. Overcoming radiation-induced PD-L1 upregulation by novel gadolinium-palladium nanoplatforms for enhanced tumor radio-immunotherapy. Chemical Engineering Journal, 2025, 504, 158754. (IF=15.1)

4. J. Cui#, G. Wang#, L. X. Yip#, M. Dong, M. Mu, L. Tian, Y. Gao, Q. Fan, Q. Zhu, X. Zhao*, X. Xu*, D. T. Leong*, X. Sun*. Enhanced ferritin-manganese interaction by nanoplatinum growth enabling liver fibrosis three-dimensional magnetic resonance visualization and synergistic therapy with real-time monitoring. Advanced Functional Materials, 2024, 2410748. (IF=19)

5. H. Liu, M. Mu, Y. Hou, Y. Gong, C. Wang, G. Ma, K. Guo, L. Ma*, X. Sun*. A Novel Encapsulated Biomimetic Manganese Sulfide Nanourchins for Targeted Magnetic Resonance Contrast Enhancement and Self-Enhanced Chemodynamics-Gene-Immune Synergistic Tumor Therapy. Advanced Functional Materials, 2024, 2401370. (IF=19)

6. G. Ma#, X. Zhang#, K. Zhao#, S. Zhang, K. Ren, M. Mu, C. Wang, X. Wang, H. Liu*, J. Dong*, X. Sun*. Polydopamine nanostructure-enhanced water interaction with pH-responsive manganese sulfide nanoclusters for tumor magnetic resonance contrast enhancement and synergistic ferroptosis-photothermal therapy. ACS Nano, 2024, 18, 4, 3369-3381. (IF=17.1)

7. H. Liu, X. Dai, N. Li, L. Zhang, Z. Wang, K. Ren, Y. Li,* X. Sun,* J. Wan*. Injectable Magnetic Hydrogel Incorporated with Anti-inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis. Advanced Science, 2024, 2409778. (IF=14.3)

8. M. Mu , M. Zhang, Y. Gong, K. Guo, H. Liu, Z. Zhang, T. Jiang, H. Zhou, Q. Fan, D. Jia*, Y. Li*, X. Sun*, A multifunctional nanoplatform capable of dual action on tumor PD-L1 for enhanced cancer theranostics. Chemical Engineering Journal, 2024, 502, 158139. (IF=15.1)

9. C. Wang, W. Tian, X. Dai, J. Yuan, N. Ni, Q. Fan, H. Liu, H. Sun*, J. Wan*, X. Sun*. Calcium ascorbate loaded ultrathin ferrous sulfide nanosheets thermo-sensitive hydrogels for near-infrared light activation of synergistic endometriosis therapy. Chemical Engineering Journal, 2024, 496, 153740. (IF=15.1)

10. S. Liu#, L. Tian#, M. Mu, Z. Liu, M. Dong, Y. Gong, X. Wang, Q. Meng*, H. Zhang*, X. Sun*. Platinum Nanoparticles-Enhanced Ferritin-Mn2+ Interaction for Magnetic Resonance Contrast Enhancement and Efficient Tumor Photothermal Therapy, Advanced Healthcare Materials, 2024, 2303939. (IF=10)

11. Y. Gong#, K. Guo#, S. Cai, K. Ren, L. Tian, Y. Wang, M. Mu, Q. Meng*, J. Liu*, X. Sun*. Customized Sized Manganese Sulfide Nanospheres as Efficient T1 MRI Contrast Agents for Enhanced Tumor Theranostics. Biomaterials Research, 2024, 28, 0116. (IF=11.6)

12. X. Xu, S. Xu, J. Wan, D. Wang, X. Pang, Y. Gao, N. Ni, D. Chen*, X. Sun*. Disturbing Cytoskeleton by Engineered Nanomaterials for Enhanced Cancer Therapeutics. Bioactive Materials, 2023, 29, 50-71. (IF=18.9)

1) X. Zhang, X. Xu, H. Liu, N. Ni, S. Liu, Y. Gong, G. Ma, L. Song, Q. Fan*, Q. Meng*, X. Sun*. CCR2-overexpressing Biomimetic Carrier-free Nanoplatform for Enhanced Cascade Ferroptosis Tumor Therapy. Acta Biomaterialia, 2023, 166, 604-614. (IF=10.6)

13. X. Zhang#, H. Ge#, Y. Ma, L. Song, Y. Ma, G. Tian, L. Wang, Q. Meng*, X. Sun*. Engineered anti-cancer nanomedicine for synergistic ferroptosis-immunotherapy. Chemical Engineering Journal, 2023, 455, 140688. (IF=15.1)

14. Y. Gao#, S. Liu#, H. Liu#, H. Ge, M. Zhang, C. Zhao, Y. Gong, X. Zhang, C. Wang*, X. Sun*, Z. Wu*. Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine. Science China Chemistry, 2023, 66, 2492-2512. (IF=10.1)

15. X. Xu, A. Liu, S. Liu, Y. Ma, X. Zhang, M. Zhang, J. Zhao, S. Sun, X. Sun*. Application of Molecular Dynamics Simulation in Self-assembled Cancer Nanomedicine. Biomaterials Research, 2023, 27, 39. (IF=11.6)

16. W. Tian, C. Wang, R. Chu, H. Ge, X. Sun*, M. Li*. Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic therapy. Biomaterials Research, 2023, 27, 100. (IF=11.6)

17. S. Xu#, X. Pang#, X. Zhang, Q. Lv, M. Zhang, J. Wang, N. Ni, X. Sun*. Nanomaterials disrupting cell-cell junctions towards various diseases. Nano Research, 2023, 16, 7053–7074. (IF=10.2)

18. N. Ni#, X. Zhang#, Y. Ma, J. Yuan, D. Wang, G. Ma, J. Dong*, X. Sun*. Biodegradable two-dimensional nanomaterials for cancer theranostics. Coordination Chemistry Reviews, 2022, 458, 214415. (IF=24.833)

19. J. Liu#, M. Huang#, X. Zhang#, Z. Hua, Z. Feng, Y. Dong, T. Sun*, X. Sun*, C. Chen*. Polyoxometalate nanomaterials for enhanced reactive oxygen species theranostics. Coordination Chemistry Reviews, 2022, 472, 214785. (IF=24.833)

20. H. Zhang#, M. Zhang#, X. Zhang, Y. Gao, Y. Ma, H. Chen, J. Wan, C. Li, F. Wang*, X. Sun*. Enhanced postoperative cancer therapy by iron-based hydrogels. Biomaterials Research, 2022, 26, 19. (IF=11.6)

21. N. Ni, W. Wang, Y. Sun, X. Sun*, D. T. Leong*. Inducible endothelial leakiness in nanotherapeutic applications. Biomaterials, 2022, 287, 121640. (IF=15.3)