一、简介

孙晓，教授，博导，山东省优青，泰山学者青年专家，山东省创新团队带头人，齐鲁卫生与健康杰出青年人才，山东省海外科技人才，国自然通讯评审专家。曾在中国科学技术大学、中科院合肥物质科学院吴正岩课题组进行直博学习和研究，此后赴新加坡国立大学David Tai Leong课题组开展博士后研究。2020年起在山东省肿瘤医院于金明院士放射免疫与分子影像平台学习。2021年加入山东第一医科大学，主要从事MRI疾病纳米诊疗体系开发等方面研究，以第一或通讯作者发表SCI论文37篇，其中IF>20有2篇，IF>10有19篇，申请发明专利21项，已授权9项；主持国家自然科学基金面上项目等国家级课题2项、省级课题5项；2023年获山东省医学会科技奖、山东省医学会青年科技奖、山东第一医科大学科学技术二等奖；2023年获校“优秀教师”、“校党支部双带头人”等荣誉称号；现为BMEMat、Exploration、Interdisciplinary Medicine、Biomedical Technology、Acta Materia Medica、Biomaterials Translational等杂志青年编委及ACS Nano、AFM、Nano Letters、Biomaterials、Small等杂志审稿人。讲授《无机化学》、《物理化学实验》、《生物医用材料》等课程。

二、研究方向

MRI分子影像探针、纳米药物、生物医用材料等

三、承担的主要科研/教改项目

1、山东第一医科大学拔尖人才启动经费，250万，2021.04-2026.04，主持

2、国家自然科学基金面上项目，50万，2024.01-2027.12，主持

3、国家自然科学基金青年项目，30万，2022.01-2024.12，主持

4、泰山学者青年专家项目，75万，2025.1-2027.12，主持

5、山东省优青项目（海外），60万，2022.05-2025.04，主持

6、山东省高校青创科技计划，50万，2022.01-2024.12，主持

7、山东省自然科学基金青年项目，15万，2022.01-2024.12，主持

8、齐鲁卫生与健康杰出青年培育工程，15万，2021.01-2025.12，主持

四、发表的主要科研/教改论文

[1] G. Ma#, X. Zhang#, K. Zhao#, S. Zhang, K. Ren, M. Mu, C. Wang, X. Wang, H. Liu*, J. Dong*, X. Sun*. Polydopamine nanostructure-enhanced water interaction with pH-responsive manganese sulfide nanoclusters for tumor magnetic resonance contrast enhancement and synergistic ferroptosis-photothermal therapy. ACS Nano, 2024, 18, 4, 3369-3381. (IF=17.1)

[2] S. Liu#, L. Tian#, M. Mu, Z. Liu, M. Dong, Y. Gong, X. Wang, H. Zhang*, Q. Meng*, X. Sun*. Platinum Nanoparticles-Enhanced Ferritin-Mn2+ Interaction for Magnetic Resonance Contrast Enhancement and Efficient Tumor Photothermal Therapy. Advanced Healthcare Materials, 2024, 2303939. (IF=10)

[3] H. Liu, M. Mu, Y. Hou, Y. Gong, C. Wang, G. Ma, K. Guo, L. Ma*, X. Sun*. A Novel CRISPR/Cas9-Encapsulated Biomimetic Manganese Sulfide Nanourchins for Targeted Magnetic Resonance Contrast Enhancement and Self-Enhanced Chemodynamics-Gene-Immune Synergistic Tumor Therapy. Advanced Functional Materials, 2024, 202401370. (IF=19)

[4] C. Wang#, W. Tian#, X. Dai#, J. Yuan, N. Ni, Q. Fan, H. Liu, H. Sun*, J. Wan*, X. Sun*. Calcium ascorbate loaded ultrathin ferrous sulfide nanosheets thermo-sensitive hydrogels for near-infrared light activation of synergistic endometriosis therapy. Chemical Engineering Journal, 2024, 496, 153740. (IF=15.1)

[5] X. Xu#, S. Xu#, J. Wan#, D. Wang, X. Pang, Y. Gao, N. Ni, D. Chen*, X. Sun*. Disturbing Cytoskeleton by Engineered Nanomaterials for Enhanced Cancer Therapeutics. Bioactive Materials, 2023, 29, 50–71. (IF=18.9)

[6] X. Zhang, H. Ge, Y. Ma, L. Song, Y. Ma, G. Tian, L. Wang, Q. Meng*, X. Sun*. Engineered Anti-cancer Nanomedicine for Synergistic Ferroptosis-Immunotherapy. Chemical Engineering Journal, 2023, 455, 140688. (IF=16.744)

[7] X. Zhang, X. Xu, H. Liu, N. Ni, S. Liu, Y. Gong, G. Ma, L. Song, Q. Fan*, Q. Meng*, X. Sun*. CCR2-overexpressing Biomimetic Carrier-free Nanoplatform for Enhanced Cascade Ferroptosis Tumor Therapy. Acta Biomaterialia, 2023, 166, 604-614. (IF=10.633)

[8] X. Xu, A. Liu, S. Liu, Y. Ma, X. Zhang, M. Zhang, J. Zhao, S. Sun, X. Sun*. Application of Molecular Dynamics Simulation in Self-assembled Cancer Nanomedicine. Biomaterials Research, 2023, 27, 39. (IF=15.863)

[9] S. Xu, X. Pang, X. Zhang, Q. Lv, M. Zhang, J. Wang, N. Ni, X. Sun*. Nanomaterials disrupting cell-cell junctions towards various diseases. Nano Research, 2023, 16, 7053–7074. (IF=10.263)

[10] W. Tian, C. Wang, R. Chu, H. Ge, X. Sun*, M. Li*. Injectable hydrogel nanoarchitectonics with near-infrared controlled drug delivery for in situ photothermal/endocrine synergistic therapy. Biomaterials Research, 2023, 27, 100. (IF=15.863)

[11] Y. Gao, S. Liu, H. Liu, H. Ge, M. Zhang, C. Zhao, Y. Gong, X. Zhang, C. Wang*, X. Sun*, Z. Wu*. Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine. Science China Chemistry, 2023, 66, 2492-2512. (IF=10.138)

[12] M. Liu, J. Yuan, G. Wang, N. Ni, Q. Lv, S. Liu, Y. Gong, X. Zhao, X. Wang*, X. Sun*. Shape Programmable T1-T2 Dual-Mode MRI Nanoprobes for Cancer Theranostics. Nanoscale, 2023, 15, 4694-4724. (IF=8.31)

[13] G. Ma, K. Wang, X. Pang, S. Xu, Y. Liang, J. Yang, X. Zhang, X. Sun*, J. Dong*. Self-assembled nanomaterials for ferroptosis-based cancer theranostics. Biomaterials Science, 2023, 11, 1962-1980. (IF=7.59)

[14] C. Wang, Y. Wang, W. Tian, S. Li, J. Wan, Y. Wang, L. Tian, X. Wang, C. Li, J. Wan*, X. Sun*. Application of nanomaterials with sulfur vacancy for enhanced cancer theranostics. Nano TransMed. 2023, 2, 100007.

[15] W. Wang, X. Pang, M. Dong, R. Li, Z. Liu, Y. Liang, H. Liu, N. Ni, D. Chen*. X. Sun*. Recent advances of nanomaterials promoting tumor metastasis. Environment & Health, 2023, 1, 367-382. (Supplementary Cover)

[16] N. Ni, X. Zhang, Y. Ma, J. Yuan, D. Wang, G. Ma, J. Dong*, X. Sun*. Biodegradable Two-Dimensional Nanomaterials for Cancer Theranostics. Coordination Chemistry Reviews, 2022, 458, 214415. (IF=24.833）

[17] J. Liu, M. Huang, X. Zhang, Z. Hua, Z. Feng, Y. Dong, T. Sun*, X. Sun*, C. Chen*. Polyoxometalate Nanomaterials for Enhanced Reactive Oxygen Species Theranostics. Coordination Chemistry Reviews, 2022, 472，214785. (IF=24.833）

[18] N. Ni, W. Wang, Y. Sun, X. Sun*, D. T. Leong*. Inducible endothelial leakiness in nanotherapeutic applications. Biomaterials, 2022, 287, 121640. (IF=15.304）

[19] H. Zhang, M. Zhang, X. Zhang, Y. Gao, Y. Ma, H. Chen, J. Wan, C. Li, F. Wang*, X. Sun*. Enhanced postoperative cancer therapy by iron-based hydrogels. Biomaterials Research, 2022, 26, 19. (IF=15.863）

[20] Y. Xu, Z. Nie, N. Ni, X. Zhang, J. Yuan, Y. Gao, Y. Gong, S. Liu, M. Wu*, X. Sun*. Shield-Activated Two-Way Imaging Nanomaterials for Enhanced Cancer Theranostics. Biomaterials Science, 2022, 10, 6893-6910. (IF=7.590)

[21] X. Sun#, R. Du#, L. Zhang#, G. Zhang, X. Zheng, J. Qian, X. Tian, J. Zhou, J. He, Y. Wang, Y. Wu, K. Zhong, D. Cai*, D. Zou*, Z. Wu*. A pH-responsive yolk-like nanoplatform for tumor targeted dual-mode magnetic resonance imaging and chemotherapy. ACS Nano, 2017, 11, 7049-7059.（IF=18.027）

[22] X. Sun#, G. Zhang#, R. Du#, R. Xu, D. Zhu, J. Qian, G. Bai, C. Yang, Z. Zhang, X. Zhang, D. Zou*, Z. Wu*. A Biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode MR imaging guided combinatorial cancer therapy. Biomaterials, 2019, 194, 151-160.（IF=15.304）

[23] X. Sun#, M. Zhang#, R. Du#, X. Zheng, C. Tang, Y. Wu, J. He, W. Huang, Y. Wang, Z. Zhang, X. Han, J. Qian, K. Zhong, X. Tian, L. Wu, G. Zhang, Z. Wu*, D. Zou*. A polyethyleneimine-driven self-assembled nanoplatform for fluorescence and MR dual-mode imaging guided cancer chemotherapy. Chemical Engineering Journal, 2018, 350, 69-78.（IF=16.744）

[24] X. Sun*, N. Ni, Y. Ma, Y. Wang, D. T. Leong*. Retooling Cancer Nanotherapeutics' Entry into Tumors to Alleviate Tumoral Hypoxia. Small, 2020, 16, 2003000.（IF=15.153）

[25] Y. Cao, K. Wang, P. Zhu, X. Zou, G. Ma, W. Zhang, D. Wang, J. Wan, Y. Ma, X. Sun*, J. Dong*. A near-infrared triggered upconversion/MoS2 nanoplatform for tumour-targeted chemo-photodynamic combination therapy. Colloids and Surfaces B: Biointerfaces, 2022, 213, 112393. (IF=5.999）