一、简介

葛燕青，教授，山东省优青，硕士生导师，2005年6月毕业于曲阜师范大学，获化学教育学士学位。2010年6月毕业于山东大学，获有机化学博士学位。2010年9月起，任职于泰山医学院化工学院(现山东第一医科大学化学与制药工程学院)。2014.12至2015.12于复旦大学化学系做访问学者(合作导师:李富友教授)，2019.01至2020.01于美国科罗拉多大学化学系做访问学者(合作导师:张伟教授)。研究方向为有机合成。主持完成国家自然科学基金1项，山东省优青1项，山东省自然科学基金项目1项和山东省青创科技支持计划1项。目前在研山东省高等学校青年创新团队-人才引育计划1项和山东省自然科学基金项目1项。在Trends Chem., Nat. Commun., Sci. China Chem., Adv. Opt. Mater. 等杂志发表第一及通讯作者SCI论文60 余篇。授权发明专利6项。获山东省高校科学技术奖三等奖一项(1/3)，山东省高校优秀科研成果奖二等奖一项(2/4)。

二、研究方向

有机发光材料的合成及其在生物医药中的应用。

三、承担的主要科研/教改项目

1. 山东省高等学校青年创新团队，2022.01-2024.12，主持人

2. 山东省自然科学基金，氮桥头杂环类跨键能量转移型探针的设计合成及用于成像检测 (ZR2021MB033)，2022.01-2024.12，主持人

3. 山东省高等学校青创科技支持计划，双光子组织成像染料的设计、合成与应用 (2019KJC009)，2019.05-2021.12，主持人

4. 山东省优青，基于氮桥头芳杂五环并吡啶-半花菁的比率型荧光探针的合成与细胞成像 (ZR2017JL015)，2017.08-2020.08，主持人

5. 国家自然科学基金，基于氮桥头芳杂五环并吡啶-罗丹明的比率型荧光探针的  设计合成与细胞成像 (21602153)，2017.01-2019.12，主持人

6. 山东省自然科学基金，7-羧基吡咯并[1,2-a]吡啶类抗病毒药物的设计、合成与活性研究 (ZR2012BL04)，2012.12-2015.12，主持人

四、发表的主要科研/教改论文

2023

(62) Wei Gao, Zhenliang Liu, Xianyin Dai, Weitao Sun, Qi Gong, Jinwei Li, and Yanqing Ge*, Color-Tunable Ultralong Organic Phosphorescence: Commercially Available Triphenylmethylamine for UV-Light Response and Anticounterfeiting, Chem. Asian J., 2023, Accepted

(61) Yongchao Li, Liqing Zhang, Xianfeng Meng, Guowei Shi, Wei Gao, Guiyun Duan*, Yanqing Ge*, Visible-light excited and highly photostable organic fluorophore with dual-state emission，J. Fluores., 2023, Accepted.

(60) Wei Gao, Xianyin Dai, Chao Hou, Weitao Sun, Qi Gong, Hongyu Chen, Yanqing Ge*, Propeller ultralong room-temperature phosphorescence: new aspect of triphenylphosphine derivatives, Adv. Opt. Mater., 2023, online.

(59) Yanqing Ge*, Wei Zhang*, Directed synthesis of isomeric 2D heteropore covalent organic frameworks, Sci. China Chem., 2023, 10.1007/s11426-023-1530-7

(58) Renle Cui, Caihong Liu, Ping Zhang, Kun Qin, Yanqing Ge*, An imidazo[1,5-a]pyridine benzopyrylium-based NIR fluorescent probe with ultra-large stokes shifts for monitoring SO2, Molecules, 2023, 28, 515.

(57) Yunlong Gao, Guangle Song, Guowei Shi, Jixiang Xiao, Chunhao Yuan, Yanqing Ge*, Simple and commercially available 6-chloroimidazo[1,2-a]pyridine-2-carboxylic acid-based fluorescent probe for monitoring pH changes, J. Fluores., 2023, 33, 305-309.

(56) Yongchao Li, Shaohong Ren, Guowei Shi, Chunhao Yuan, Guiyun Duan*, Yanqing Ge*, Simple and commercially available imidazo[1,2-a]pyridine- 8-carboxylic acid-based fluorescent pH probe for basic conditions, J. Lumin., 2023, 255, 119547.

(55) Guowei Shi, Haiyan Ge, Liqing Zhang, Yongchao Li, Renle Cui, Lacey J. Wayment, Yanqing Ge*, Wei Zhang*, Organic fluorophores with high photostability and strong emission in both solution and solid state, J. Lumin., 2023, 253, 119447.

2022

(54) Hao Liu, Shaohong Ren, Chuanjun Ma, Guowei Shi, Yongchao Li, Guiyun Duan*, Yanqing Ge*, Copper-promoted direct decarboxylative C3-acylation of electron-rich indolizines using α-keto acids, ChemistrySelect., 2022, online.

(53) Renle Cui, Yunlong Gao, Haiyan Ge, Guowei Shi, Yongchao Li, Hao Liu, Chuanjun Ma, Yanqing Ge*, Caihong Liu*, A turn-on fluorescent probe based on indolizine for detection of sulfite, New J. Chem., 2022, 46, 8088-8093.

(52) Yanqing Ge*, Yiming Hu, Guiyun Duan, Yinghua Jin, Wei Zhang*, Advances and challenges in user-friendly alkyne metathesis catalysts, Trends Chem., 2022, 4, 540-553.

2021  

(51) Huawei Lin, Huimin Yang, Qi Gong, Shan Luo, Jing Gu, Xiaoqun Cao, Biming Mao, Yanqing Ge*, Chunhao Yuan*, Construction of cyclopentane-fused coumarins via DBU-catalyzed [3+2] cycloaddition of 3-homoacyl coumarins with cyclic 1-azadienes, RSC Adv., 2021, 11, 20118-20122.

(50) Guiyun Duan, Hao Liu, Liqing Zhang, Chunhao Yuan, Yongchao Li, Yanqing Ge*, Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process, RSC Adv., 2021, 11, 25624-25627.

(49) Gui Yun Duan1, Hong Wang1, Hong Sun, Chunhao Yuan, Zhiyang Xu, Yan Qing Ge*, Near-infrared TBET cassette with ultra large stokes shift and its application for SO2 imaging in cells, Chem. Eng. J. Adv., 2021, 8, 100141.

(48) Yanhao Xu1, Ruikang Duan1, Hao Liu, Chengcai Xia, Guiyun Duan, Yanqing Ge*, Preparation of a novel pH-responsive fluorescent probe based on an imidazo[1,2-a]indole fluorophore and its application in detecting extremely low pH in Saccharomyces cerevisiae, J. Fluores., 2021, 31, 1219-1225.

(47) Chuanjun Ma1, Liqing Zhang1, Linlin Hou, Fahong Chen, Aikun Liu, Ruixue Ji, Qingfeng Wang, Chunhao Yuan, Yanqing Ge*, A fluorescent probe with a large Stokes shift for sensing sulfite in dry white wine based on pyrazolo[1,5- a]pyridine fluorophore, Tetrahedron Lett., (2021) 153210.

(46) Yanyan Li1, Gongxiao Zhang1, Chuanjun Ma, Fahong Chen, Jian Dong*, Yanqing Ge*, A simple dual-channel imidazo[1,5-a]pyridine-based fluorescent probe for the discrimination between Cys/Hcy and GSH, Dyes Pigm., 2021, 191, 109381.

2020

(45) Yanqing Ge, Shaofeng Huang, Yiming Hu, Lei Zhang, Ling He, Sebastian Krajewski, Michael Ortiz, Yinghua Jin, Wei Zhang*, Highly active alkyne metathesis catalysts operating under open air condition, Nat. Commun., 2021, 12, 1136.

2019

(44) Yanzhong Li, Sijia Qi, Chengcai Xia, Yanhao Xu, Guiyun Duan*, Yanqing Ge*, A FRET ratiometric fluorescent probe for detection of Hg2+ based on an imidazo[1,2-a]pyridine-rhodamine system, Anal. Chim. Acta, 2019, 1077, 243-248.

(43) Zebao Zheng*, Jichun Cui, Yinfeng Han, Yanqing Ge*, Jian Zuo, Wenxi Hao, Development of fast-response turn-on phosphorescent probes for biothiols based on ruthenium(II) complexes, Anal. Methods, 2019, 11, 2341-2350.

(42) Zebao Zheng*, Yinfeng Han, Yanqing Ge*, Jichun Cui, Jian Zuo, Kun Nie, Rapid and selective detection of biothiols by novel ruthenium(II) complex-based phosphorescence probes, Spectrochim. Acta Part A., 2019, 216, 328-334.

(41) Guiyun Duan, Gongxiao Zhang, Shuqing Yuan, Ruixue Ji, Litao Zhang, Yanqing Ge*, A pyrazolo[1,5-a]pyridine-based ratiometric fluorescent probe for sensing Cu2+ in cell, Spectrochim. Acta Part A., 2019, 219, 173-178.

(40) Zhiyang Xu, Hong Wang, Zhen Chen, Hongli Jiang, Yanqing Ge*, Near-infrared fluorescent probe for selective detection of Cu2+ in living cells and in vivo, Spectrochim. Acta Part A., 2019, 216, 404-410.

(39) Zhiyang Xu, Zhen Chen, Aikun Liu, Ruixue Ji, Xiaoqun Cao, Yanqing Ge*, A ratiometric fluorescent probe for detection of exogenous mitochondrial SO2 based on a FRET mechanism, RSC Adv., 2019, 9, 8943-8948.

(38) Fahong Chen, Aikun Liu, Ruixue Ji, Zhiyang Xu, Jian Dong*, Yanqing Ge*, A FRET-based probe for detection of the endogenous SO2 in cells, Dyes Pigm., 2019, 165, 212-216.

(37) Dongsheng Zhang, Aikun Liu, Ruixue Ji, Jian Dong, Yanqing Ge*, A mitochondria-targeted and FRET-based ratiometric fluorescent probe for detection of SO2 derivatives in water, Anal. Chim. Acta, 2019, 1055, 133-139.

(36) Gongxiao Zhang, Ruixue Ji, Xiangyu Kong, Fujiao Ning, Aikun Liu, Jichun Cui, Yanqing Ge*, A FRET based ratiometric fluorescent probe for detection of sulfite in food, RSC Adv., 2019, 9, 1147-1150.

(35) Guangle Song, Aikun Liu, Hongli Jiang, Ruixue Ji, Jian Dong, Yanqing Ge*, A FRET-based ratiometric fluorescent probe for detection of intrinsically generated SO2 derivatives in mitochondria, Anal. Chim. Acta, 2019, 1053, 148-154.

2018

(34) Peiling Yan, Guiyun Duan, Ruixue Ji, Yanqing Ge*, A simple and efficient synthesis of new fluorophore 4-hydroxy pyrazolo[1,5-a]pyridines through a tandem reaction, Tetrahedron Lett., 2018, 59, 2426-2429.

(33) Ruixue Ji, Kun Qin, Aikun Liu, Yan Zhu, Yanqing Ge*, A simple and fast- response fluorescent probe for hypochlorite in living cells, Tetrahedron Lett., 2018, 59, 2372-2375.

(32) Guangjie Song, Jing Luo, Xujiao Xing, Hanlin Ma, Di Yang, Xiaoqun Cao*, Yanqing Ge*, Baoxiang Zhao, A ratiometric fluorescence probe for rapid detection of mitochondrial SO2 derivatives, New J. Chem., 2018, 42, 3063-3068.

(31) Ping Zhang, Huaying Lv, Guiyun Duan, Jian Dong, Yanqing Ge*, A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells, RSC Adv., 2018, 8, 30732-30735.

(30) Yanqing Ge, Peng Wei, Teng Wang, Xiaoqun Cao*, Dongsheng Zhang, Fuyou Li, A simple fluorescent probe for monitoring pH in cells based on new fluorophore pyrido[1,2-a]benzimidazole, Sens. Actuators B, 2018, 254, 314-320.

2017

(29) Yanqing Ge#, Xujiao Xing#, Aikun Liu, Ruixue Ji, Shili Shen, Xiaoqun Cao*, A novel imidazo[1,5-a]pyridine-rhodamine FRET system as an efficient ratiometric fluorescent probe for Hg2+ in living cells, Dyes Pigm., 2017, 146, 136-142.

(28) Yanqing Ge#, Aikun Liu#, Ruixue Ji, Shili Shen, Xiaoqun Cao*, Detection of Hg2+ by a FRET ratiometric fluorescent probe based on a novel pyrido[1,2-a] benzimidazole-rhodamine system, Sens. Actuators B, 2017, 251, 410-415.

(27) Aikun Liu, Ruixue Ji, Shili Shen, Xiaoqun Cao, Yanqing Ge*, A ratiometric fluorescent probe for sensing sulfite based on a pyrido[1,2-a]benzimidazole fluorophore, New J. Chem., 2017, 41, 10096-10100.

(26) Yanqing Ge, Aikun Liu, Jiang Dong, Guiyun Duan, Xiaoqun Cao*, Fuyou Li, A simple pH fluorescent probe based on new fluorophore indolizine for imaging of living cells, Sens. Actuators B, 2017, 247, 46-52.

(25) Xiaoling Zheng, Ruixue Ji, Xiaoqun Cao, Yanqing Ge*, FRET-based ratiometric fluorescent probe for Cu2+ with a new indolizine fluorophore, Anal. Chim. Acta, 2017, 978, 48-54.

(24) Yanqing Ge, Ruixue Ji, Shili Shen, Xiaoqun Cao*, Fuyou Li，A ratiometric fluorescent probe for sensing Cu2+ based on new imidazo[1,5-a]pyridine fluorescent dye, Sens. Actuators B, 2017, 245, 875-881.

(23) Yanqing Ge, Xiaoling Zheng, Ruixue Ji, Shili Shen, Xiaoqun Cao*, A new pyrido[1,2-a]benzimidazole-rhodamine FRET system as an efficient ratiometric fluorescent probe for Cu2+ in living cells, Anal. Chim. Acta, 2017, 965, 103-110.

(22) Xiansheng Zhang, Bin Wang, Jiong Jia, Yanqing Ge*, Jianwu Wang*, Synthesis of 7-cyanoindolizine derivatives via a tandem reaction, Heterocycl. Commun., 2017, 23, 71-74.

(21) Zhe Han, Jing Yan, Houquan Tang, Yuan He, Ying Zhu*, Yanqing Ge*, Novel simple fluorescent sensor for nickel ions, Tetrahedron Lett., 2017, 58, 1254-1257.

(20) Ruixue Ji, Aikun Liu, Shili Shen, Xiaoqun Cao, Fei Li, Yanqing Ge*, An indolizine-rhodamine based FRET fluorescence sensor for highly sensitive and selective detection of Hg2+ in living cells, RSC Adv., 2017, 7, 40829-40833.

2016

(19) Qizhang Huang, Jifu Shi*, Xueqing Xu, Leilei Wang, Liuwen Zhong, Yaoming Sun, Hai Wang, Gang Xu, Yanqing Ge*, All-solid-state nanocomposite electrolytes composed of an ionic polymer with polar groups and surface-modified SiO2 nanoparticles for dye-sensitized solar cells, RSC Adv., 2016, 6, 79844-79852.

2015

(18) Yanqing Ge, Xueyong Gong, Guangjie Song, Xiaoqun Cao*, Jianwu Wang*, The synthesis, characterization and optical properties of novel 2-acyl 6- arylindolizines, Spectrochim. Acta Part A., 2015, 135, 7-13.

(17) Bin Wang, Fan Su, Jiong Jia, Fan Wu, Shuyao Zhang, Yanqing Ge*, Jason Wang, Jianwu Wang*, Synthesis of 5-cyanopyrazolo[1,5-a]pyridine derivatives via tandem reaction and their optical properties, Tetrahedron Lett., 2015, 56, 425-429.

2014

(16) Yanqing Ge#, Furong Li#, Yujuan Zhang#, Yushui Bi, Xiaoqun Cao*, Guiyun Duan, Jianwu Wang, Zhenliang Liu, Synthesis, crystal structure, optical properties and antibacterial evaluation of novel imidazo[1,5-a]pyridine derivatives bearing a hydrazone moiety, Luminescence, 2014, 29, 293-300.

(15) Yanqing Ge, Jiong Jia, Teng Wang, Hongwei Sun, Guiyun Duan, Jianwu Wang*, The synthesis, characterization and optical properties of novel 5-(3-aryl-1H- pyrazol-5-yl)-2-(3-butyl-1-chloroimidazo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole, Spectrochim. Acta Part A., 2014, 123, 336-341.

2013

(14) Wenjing Zhao, Yafei Xie, Yanqing Ge*, Weiren Xu, Guilong Zhao, Jianwu Wang*, Facile synthesis of pyrido[1,2-a]benzimidazole derivatives  via novel tandem reaction involving Horner-Emmons reaction, Heterocycles, 2013, 87, 1121-1126.

(13) Weiming Zhao, Yanqing Ge*, Weiren Xu, Guilong Zhao, Jiong Jia, Jianwu Wang*, A new method for the synthesis of [1,2,4]triazolo[1,5-a]pyridine derivatives, Heterocycles, 2013, 87, 869-876.

2012

(12) Xiaoqun Cao, Xiaohui Lin, Yan Zhu, Yanqing Ge*, Jianwu Wang*, The optical properties, synthesis and characterization of novel 5-aryl-3-benzimidazolyl-1 -phenyl-pyrazoline derivatives, Spectrochim. Acta Part A., 2012, 98, 76-80.

(11) Yanqing Ge, Teng Wang, Guiyun Duan, Lihua Dong, Xiaoqun Cao*, Jianwu Wang*, Synthesis, characterization, optical properties and theoretical studies of novel substituted imidazo[1,5-a]pyridinyl 1,3,4-oxadiazole derivatives, J. Fluoresc., 2012, 22, 1531-1538.

2011  

(10) Yanqing Ge, Benqian Hao, Guiyun Duan*, Wang Jianwu, The synthesis, characterization and optical properties of novel 1,3,4-oxadiazole-containing imidazo[1,5-a]-pyridine derivatives, J. Lumin., 2011, 131, 1070-1076.

(9) Yanqing Ge#, Jiong Jia#, He Yang, Xutang Tao*, Jianwu Wang*, The synthesis, characterization and optical properties of novel pyrido[1,2-a]-benzimidazole derivatives, Dyes Pigm., 2011, 88, 344-349.

(8) Yanqing Ge, Haiyan Ge, Xiaoqun Cao*, Ethyl 2-methyl-4-phenylpyrido[1,2-a] benzimidazole-3-carboxylate, Acta Crystallogr. Sect. E: Struct. Rep. Online, 2011, 67, O2846.

(7) Yanqing Ge*, Jimei Zhang, Guangliang Wang, Hao Xu, Bo Shi, Ethyl 1-(4- chlorobenzyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylate, Acta Crystallogr. Sect. E: Struct. Rep. Online, 2011, 67, O1387.

(6) Jiong Jia#, Yanqing Ge#, Xutang Tao*, Jianwu Wang*, Facile synthesis of imidazo [1,2-a] pyridines via tandem reaction, Heterocycles, 2011, 81, 185-194.

Before 2010

(5) Yanqing Ge, Jiong Jia, He Yang, Guilong Zhao, Fuxu Zhan, Jianwu Wang*, A facile approach to indolizines via tandem reaction, Heterocycles, 2009, 78, 725-736.

(4) Yanqing Ge, Jiong Jia, Yan Li, Ling Yin, Jianwu Wang*, A novel and efficient approach to pyrazolo[1,5-a]pyridine derivatives via one-pot tandem reaction, Heterocycles, 2009, 78, 197-206.

(3) Yanqing Ge, Yong Xia, Fang Wei, Wenliang Dong, Baoxiang Zhao*, N-Benzyl-5-phenyl-1H-pyrazole-3-carboxamide, Acta Crystallogr. Sect. E: Struct. Rep. Online, 2007, 63, 1186-1187.

(2) Yanqing Ge, Yong Xia, Wenliang Dong, Fang Wei, Baoxiang Zhao*, 2-{5-[N-(4-tert-Butylbenzyl)carbamoyl]-3-phenyl-1H-pyrazol-1-yl}acetic acid, Acta Crystallogr. Sect. E: Struct. Rep. Online, 2007, 63, 1287-1288.

(1) Yanqing Ge, Wenliang Dong, Yong Xia, Fang Wei, Baoxiang Zhao*, Ethyl 3-(2-hydroxy-5-methylphenyl)-1H-pyrazole-5-carboxylate, Acta Crystallogr. Sect. E: Struct. Rep. Online, 2007, 63, 1313-1314.