一、简介

袁春浩，博士，山东第一医科大学（山东省医学科学院）化学与制药工程学院讲师/硕导。2017年博士毕业于中国农业大学。主持国家自然科学基金青年基金项目“发展金属催化的烯基环丁烷、烯基氮杂环丁烷及烯基氧杂环丁烷参与的不对称环加成反应”，主持山东省自然科学基金联合专项“Azaoxyallyl正离子参与的[3+n]环加成反应的研究”，以第一作者或通讯作者身份在Organic Letters、Advanced Synthesis & Catalysis、Ecotoxicology and Environmental Safety、Organic & Biomolecular Chemistry、RSC Advances以及ChemistrySelect发表SCI论文11篇，以第一完成人身份申请发明专利一项。

二、研究方向

1.新型杂环药物的创制

2.有机及金属催化剂催化下原位生成的两性离子参与的环加成及环化反应

3.纳米药物的创制及其机理研究

三、承担的主要科研/教改项目

1.国家自然科学基金-青年基金（编号：21801180），项目名称：展金属催化的烯基环丁烷、烯基氮杂环丁烷及烯基氧杂环丁烷参与的不对称环加成反应，2019.01-2021.12，主持人（第一位）。

2. 山东省自然科学基金-联合专项（编号：ZR2018LB010），项目名称：Azaoxyallyl正离子参与的[3+n]环加成反应的研究，2018.04-2020.12，主持人（第一位）。

3. 山东省化学教指委重点教改项目，《药物合成化学》课程思政设计与实施探索（SDHX-ZD-2022-9），主持人（第一位）。

四、发表的主要科研/教改论文

11. Yue Wang+, Tingjie Huang+, Tao Zhang +, Xiaoping Ma, Guangshuo Zhou, Meiyao Chi, Xinjie Geng, Chunhao Yuan* and Nan Zou*, Residue Levels and Dietary Intake Risk Assessments of 139 Pesticides in Agricultural Produce Using the m-PFC Method Based on SBA-15-C18 with GC-MS/MS, Molecules, 2023, 28, 2480.

10. Huawei Lin, Xianru Yang, Wenyue Ning, Xiaofang Huang, Xiaoqun Cao, Yanqing Ge, Biming Mao, Chang Wang,* Hongchao Guo, and Chunhao Yuan*, Palladium-Catalyzed Asymmetric Cascade Intramolecular Cyclization/Intermolecular Michael Addition Reaction of Allenyl Benzoxazinones with 1‑Azadienes, Org. Lett. 2022, 24, 9442−9446.

9. Huawei Lin+, Jing Gu+, Shan Luo, Qilong Gu, Xiaoqun Cao, Yanqing Ge, Chang Wang,* Chunhao Yuan* and Hai Wang *，DBU-Catalyzed [3+2] Cycloaddition of Benzoaurones with 3-Homoacyl Coumarins: Synthesis of Spiro [Benzofuranone -Cyclopentane] Compounds, ChemistrySelect, 2022, 7, e202201599.

8. Chunhao Yuan*, Huimin Yang, Qi Gong, Shan Luo, Jing Gu, Yanqing Ge, Hongchao Guo*, Lei Xie, Brønsted Base-Catalyzed Tandem [2 + 4] Annulation/Tautomerization/Aromatization Reaction of α-Alkylidene Succinimides with 5-Alkenyl Thiazolones, Adv. Synth. Catal., 2021, 363, 3336-3347. (IF = 5.851)

7. Huawei Lin, Huimin Yang, Qi Gong, Shan Luo, Jing Gu, Xiaoqun Cao, Biming Mao*, Yanqing Ge*, Chunhao Yuan*, Construction of cyclopentane-fused coumarins via DBU-catalyzed [3+2] cycloaddition of 3-homoacyl coumarins with cyclic 1-azadienes, RSC Adv., 2021, 11, 20118–20122. (IF = 3.119)

6. Tingting Liu, Chunhao Yuan, Yue Gao, Jian Luo, Song Yang, Shangke Liu, Ruchang Zhang, Nan Zou*, Exogenous salicylic acid mitigates the accumulation of some pesticides in cucumber seedlings under different cultivation methods, Ecotoxicol. Environ. Saf., 198 (2020) 110680. (IF = 6.291)（共同一作第二位）

5. Chunhao Yuan*, Hui Zhang, Mengna Yuan, Lei Xie, Xiaoqun Cao*, Synthesis of 1,4-diazepinone derivatives via a domino aza-Michael/SN2 cyclization of 1-azadienes with α-halogenoacetamides, Org. Biomol. Chem., 2020, 18, 1082–1086.(IF = 3.412)

4. Yuan Chunhao, Liu Honglei, Gao Zhenzhen, Zhou Leijie, Feng Yalin, Xiao Yumei, and Guo Hongchao *. Cu(I)-Catalyzed Highly Enantioselective [3+3] Cycloaddition between Two Different 1,3-Dipoles, Phthalazinium Dicyanomethanides and Iminoester-Derived Azomethine Ylides, Org. Lett. 2015, 17, 26-29.

3. Yuan Chunhao, Zhou Leijie, Xia Miaoren, Sun Zhanhu, Wang Dongqi, and Guo Hongchao*. Phosphine-Catalyzed Enantioselective [4+3] Annulation of Allenoates with C,N-Cyclic Azomethine Imines: Synthesis of Quinazoline-Based Tricyclic Heterocycles and Their Diverse Transformations, Org. Lett. 2016, 18, 5644-5647.

2. Yuan Chunhao, Zhou Leijie, Sun Zhanhu, Guo Hongchao*, et al. Phosphine-catalyzed [3+2] cycloaddition of phthalazinium dicyanomethanides with allenoates: highly efficient synthesis of 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, RSC Adv. 2016, 6, 77931-77936.

1. Yuan Chunhao, Guo Hongchao*, et al. [5+3] Cycloaddition of Zwitterionic Allylpalladium Intermediates with 1,3-Dipoles for Construction of N,O-Containing Eight-Membered Heterocycles. Adv. Synth. Catal. 2018, 360, 652 –658.

五、授权的主要专利

1.发明专利（202110317374.6，首位）：一种环戊烷并香豆素类化合物及其制备方法，申请日期：2021.3.23