一、简介

安瑞冰，男，硕士生导师，博士后导师，校骨干人才。2020年博士毕业于南京大学化学化工学院，导师为叶德举教授；2020~2022年在南京大学生命科学学院/化学和生物医药创新研究院开展博士后研究，导师为戈惠明教授。2022年9月加入化学与制药工程学院，主要从事分子影像探针、分子诊疗探针和智能药物递送体系的构建及其生物医学应用方面的研究，目前在Nat. Commun., Angew. Chem. Int. Ed., ACS Nano, Theranostics, Chem. Sci., Sens. Actuators B Chem., J. Colloid Interface Sci., Chem. Eur. J., Anal. Chem., Analyst, Colloids Surf. B: Biointerfaces., ACS Appl. Bio Mater.，Molecules等国际权威杂志发表SCI近20篇。目前受邀成为Frontiers in Chemistry期刊的评审编辑（Review Editor）。

二、研究方向

1. 分子影像探针

2. 分子诊疗探针

3. 智能药物递送体系

三、承担的主要科研/教改项目

1. 山东第一医科大学骨干人才启动经费，200万，2022-2027，主持

2. 中国博士后科学基金面上资助项目，2021-2022，主持

3. 国家自然科学基金面上项目，2018-2021，参与

四、发表的主要科研/教改论文

1. Lingjun Liu#, Junya Zhang#, Ruibing An#, Qi Xue, Xi Cheng, Yuxuan Hu, Zheng Huang, Luyan Wu, Wenhui Zeng, Yinxing Miao, Jie Li, Yu Zhou, Hong-Yuan Chen, Hong Liu, Deju Ye. Smart Nanosensitizers for Activatable Sono‐Photodynamic Immunotherapy of Tumors by Redox‐Controlled Disassembly, Angew. Chem. Int. Ed., 2023, 62, e202217055.

2. Ruibing An, Lingjun Liu, Shixuan Wei, Zheng Huang, Ling Qiu, Jianguo Lin, Hong Liu, Deju

Ye. Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics, ACS Nano, 2022, 16, 20607-20621.

3. Rui Zhang#, Ruibing An#, Zhanni Gu, Haifeng Sun, Deju Ye* Hong Liu*. Dehydroberberine Analogue Nanoassemblies for Inducing and Self-Reporting Mitochondrial Dysfunction in Tumor Cells. ACS Appl. Bio Mater. 2021, 4, 3, 2033–2043.

4. Zheng Huang#, Ruibing An#, Shixuan Wei, Jinfang Wang*, and Deju Ye*. Noninvasive ratiometric fluorescence imaging of γ-glutamyltransferase activity using an activatable probe. Analyst, 2021, 146, 1865-1871.

5. Ruibing An, Xiaoyang Cheng, Shixuan Wei, Yuxuan Hu, Yidan Sun, Zheng Huang, Hong-Yuan Chen, Deju Ye*. Smart Magnetic and Fluorogenic Photosensitizer Nanoassemblies Enable Redox-Driven Disassembly for Photodynamic Therapy. Angew. Chem. Int. Ed., 2020, 59, 20636–20644.

6. Ruibing An, Shixuan Wei, Zheng Huang, Fei Liu, Deju Ye*. An Activatable Chemiluminescent Probe for Sensitive Detection of γ-Glutamyl Transpeptidase Activity in Vivo. Anal. Chem., 2019, 91, 13639-13646.

7. Ruibing An, Zhanni Gu, Haifeng Sun, Yuxuan Hu, Runqi Yan, Deju Ye* and Hong Liu*. Self‐assembly of Fluorescent Dehydroberberine Enhances Mitochondria‐Dependent Antitumor Efficacy. Chem. Eur. J., 2018, 24, 9812-9819.

8. Ruibing An, Datong Zhang∗ Yan Chen, Yue-zhi Cui. A novel “turn-on” fluorescent and colorimetric sensor for selective detection of Cu2+ in aqueous media and living cells. Sensors and Actuators B, 2016, 222, 48-54.

9. Ruibing An, Peng Wei, Datong Zhang*, Na Su. A highly selective 7-hydroxy-3-methyl-benzoxazinone based fluorescent probe for instant detection of thiophenols in environmental samples. Tetrahedron Lett. 2016, 57, 3039-3042.