一、简介

蒋如剑，副教授，硕士生导师（制药工程学，生物与医药方向），博士后合作导师，化学与制药工程学院/医学科技创新中心骨干人才。2021年6月毕业于吉林大学，获博士学位，师从任露泉院士。同年7月入驻济南医学科技创新中心，组建“功能仿生医用材料研究团队”，团队目前已有常驻教师4人，全职博后1人，博士研究生1人，硕士研究生9人。目前已发表SCI文章10余篇，相关成果发表在Materials Today; Chemical Engineering Journal; ACS Applied Materials & Interfaces等国际高水平期刊；合编英文论著《Bioinspired Antifouling Surfaces》。主持国家自然科学基金、山东省自然科学基金、山东省中医药科技面上项目、山东第一医科大学骨干人才等项目，累计经费250余万元。曾获得山东省优秀硕士论文、国际仿生大赛三等奖、中国材料研究学会-新材料创新创业型青年学者等荣誉。

 二、代表性论文发表： 

（1）Yuxiang Chen, Ji Ao, Jiteng Zhang, Jie Gao, Lingwan Hao, Rujian Jiang,* Zhihui Zhang, Zhenning Liu, Jie Zhao,* and Luquan Ren, Bioinspired Superhydrophobic Surfaces, Inhibiting or Promoting Microbial Contamination. Materials Today, 67 (2023) 468-494. (IF= 24.2，通讯作者) 

（2）Xin Zhang, Jiteng Zhang, Xiaoli Han, Shengnan Wang, Lingwan Hao, Chengchun Zhang, Yong Fan,* Jie Zhao,* Rujian Jiang,* Luquan Ren, A Versatile and Sustainable Strategy for Improving Mechano-Bactericidal Property of Polymeric Nanopillars. Journal of Colloid and Interface Science, 645 (2023) 380–390. (IF= 9.9，通讯作者) 

（3）Yuxiang Chen, Jie Gao, Ji Ao, Jiteng Zhang, Rujian Jiang,* Zhihui Zhang, Zhenning Liu, Jie Zhao,* Luquan Ren, Bioinspired nanoflakes with antifouling and mechano-bactericidal capacity, Colloids and Surfaces B-Biointerfaces, 224 (2023) 113229. (IF= 5.9，通讯作者) 

（4）Lingwan Hao#, Rujian Jiang#, Jie Gao, Jia-ning Xu, Limei Tian, Xu Zhang, Shengzhu Zhou, Jie Zhao*; Luquan Ren, Metal-organic framework (MOF)-based slippery liquid-infused porous surface (SLIPS) for purely physical antibacterial applications, Applied Materials Today, 2022, 27: 101430; (IF= 8.3) 

（5）Jiang, R.; Yi, Y.; Hao, L.; Chen, Y.; Tian, L.; Dou, H.; Zhao, J.; Ming, W.; Ren, L. Thermoresponsive Nanostructures: From Mechano Bactericidal Action to Bacteria Release, ACS Applied Materials & Interfaces 2021, 13, 60865-60877. （IF= 10.383） 

（6）Jiang, R.; Hao, L.; Song, L.; Tian, L.; Fan, Y.; Zhao, J.; Liu, C.; Ming, W.; Ren, L. Lotus-leaf-inspired hierarchical structured surface with non-fouling and mechanical bactericidal performances. Chemical Engineering Journal, 2020, 398, 125609.（IF= 16.744） 

（7）Jiang, R., Yan, S., Tian, L., Xu, S., Xin, Z., Luan, S., Yin J., Ren L., Zhao, J.. A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks. Chinese Journal of Polymer Science, 2018, 36(5), 576-583. (IF = 3.603) 

（8）Jiang, R.#; Xin, Z.; Xu, S.; Shi, H.; Yang, H.; Song, L.; Yan, S.# Luan, S.; Yin, J.; Khan, A.; Li, Y.; Enzyme-mimicking polymer brush-functionalized surface for combating biomaterial-associated infections. Applied Surface Science, 2017, 423, 869-880. (IF = 6.707) 

（9）Yi, YZ; Jiang, R; Liu, ZT; Dou, HX; Song, LJ; Tian, LM; Ming, WH; Ren, LQ; Zhao, J.; Bioinspired nanopillar surface for switchable mechano-bactericidal and releasing actions. Journal of Hazardous Materials, 2022, 432: 128685. (IF= 14.224) 

（10）L. Hao, R. Jiang, Y. Fan, J.-n. Xu, L. Tian, J. Zhao, W. Ming, L. Ren, Formation and antibacterial performance of metal-organic framework (MOF) films via dopamine-mediated fast assembly under visible light, ACS Sustainable Chemistry & Engineering 2020, 8, 15834−15842. （IF= 9.224） 

三、课题组当前研究方向 

团队目前主要围绕细菌感染、炎症反应、组织损伤、疾病检测等相关疾病和技术开展研究工作，具体研究方向如下： 

1.生物医用材料表面生物学性能调控 聚焦于：植/介入类材料表面物理、化学性质与细菌/细胞的互作效应研究； 

2.创面伤口愈合策略 聚焦于：兼具杀菌-抗炎-促愈合一体化纳米药物研发；

3.运动损伤康复研究 聚焦于：肌肉损伤快速修复策略研发。 

4.智能可穿戴诊疗一体化系统研发 聚焦但不限于：表面增强拉曼散射效应的特性研究，表面增强拉曼光谱结合机器学习实现疾病诊断的应用研究