一、简介

蒋如剑，副教授，硕士生导师（制药工程学，生物与医药、工业药学方向），博士后合作导师，化学与制药工程学院/医学科技创新中心骨干人才。2021年6月毕业于吉林大学，获博士学位，师从任露泉院士。同年7月入驻济南医学科技创新中心，组建“功能仿生医用材料研究团队”，团队目前已有常驻教师4人，博士后2人，博士研究生1人，硕士研究生7人。目前已发表SCI文章10余篇，相关成果发表在Materials Today; Chemical Engineering Journal; ACS Applied Materials & Interfaces等国际高水平期刊；合编英文论著《Bioinspired Antifouling Surfaces》。主持国家自然科学基金、山东省自然科学基金、山东省中医药科技面上项目、山东第一医科大学骨干人才等项目，累计经费250余万元。曾获得山东省优秀硕士论文、国际仿生大赛三等奖、中国材料研究学会-新材料创新创业型青年学者等荣誉。

 二、代表性论文发表： 

（1）Yuxiang Chen, Ji Ao, Jiteng Zhang, Jie Gao, Lingwan Hao, Rujian Jiang,* Zhihui Zhang, Zhenning Liu, Jie Zhao,* and Luquan Ren, Bioinspired Superhydrophobic Surfaces, Inhibiting or Promoting Microbial Contamination. Materials Today, 67 (2023) 468-494. (IF= 24.2，通讯作者)；

（2）Ruixiao Wang, Yanhong Dong, Jiteng Zhang, Lingwan Hao*, Lu Zhou, Liwei Sun, Yan Song, Rujian Jiang*, Xiaolin Qi*, A multifunctional nanoplatform with dual-targeted antibacterial and cascaded immunomodulatory strategy for the treatment of bacterial keratitis, Chemical Engineering Journal 2024, 498, 155323.（IF= 13.3，中科院一区）；

（3）Ji Ao; Xin Zhang; Yunhao You; Yuxiang Chen; Chenyang Qin; Lingwan Hao*; Jie Gao; Zequan Liu; Jie Zhao*; Rujian Jiang*, Bioinspired Hybrid Nanostructured PEEK Implant with Enhanced Antibacterial and Anti-inflammatory Synergy, ACS Applied Materials & Interfaces, 2024, 16, 38989−39004. （IF= 8.3，中科院二区）；

（4）Liwei Sun, Xu Zhang, Jiteng Zhang, Xinmeng Li, Jie Zhao, Rujian Jiang*, Lingjie Song* and Shifang Luan, Endogenous Stimulation-driven Janus Mesh with Antibacterial, Anti-adhesive and Prohealing Performances for Hernia Repair, Chemical Engineering Journal, 2024, 494, 152764. (IF= 13.3，中科院一区)；

（5）Zhi Qu, Yang Wang, Yanhong Dong, Xinmeng Li, Lingwan Hao*, Liwei Sun, Lu Zhou, Rujian Jiang*, Weihua Liu*, Intelligent Electrospinning Nanofibrous Membranes for Monitoring and Promotion of the Wound Healing. Materials Today Bio, 2024, 26, 101093.. (IF= 8.2，中科院一区)；

（6）Lingwan Hao, Jie Gao, Xiaoli Han, Zexiang Li, Yanhong Dong*, Liwei Sun, Lu Zhou, Jie Zhao, Rujian Jiang*, A Sunlight Sensitive Metal-organic Frameworks Film for the Environment-friendly Self-sterilization Application. Inorganic Chemistry Frontiers, 2024, 11, 4229–4240. (IF= 7.0，中科院一区)；

（7）Xin Zhang, Jiteng Zhang, Xiaoli Han, Shengnan Wang, Lingwan Hao, Chengchun Zhang, Yong Fan,* Jie Zhao,* Rujian Jiang,* Luquan Ren, A photothermal therapy enhanced mechano-bactericidal hybrid nanostructured surface. Journal of Colloid and Interface Science, 645 (2023) 380–390. (IF= 9.9，通讯作者)；

（8）Yuxiang Chen, Jie Gao, Ji Ao, Jiteng Zhang, Rujian Jiang,* Zhihui Zhang, Zhenning Liu, Jie Zhao,* Luquan Ren, Bioinspired nanoflakes with antifouling and mechano-bactericidal capacity, Colloids and Surfaces B-Biointerfaces, 224 (2023) 113229. (IF= 5.9，通讯作者)；

（9）Limei TIAN, Jie ZHAO, Huichao JIN, Wei BING and Rujian JIANG， Bioinspired Antifouling Surfaces： From Marine Applications to Biomedical Protections, Current Natural Sciences, (2022，论著)；

（10）Lingwan Hao#, Rujian Jiang#, Jie Gao, Jia-ning Xu, Limei Tian, Xu Zhang, Shengzhu Zhou, Jie Zhao*; Luquan Ren, Metal-organic framework (MOF)-based slippery liquid-infused porous surface (SLIPS) for purely physical antibacterial applications, Applied Materials Today, 2022, 27: 101430; (IF= 8.3)；

（11）Jiang, R.; Yi, Y.; Hao, L.; Chen, Y.; Tian, L.; Dou, H.; Zhao, J.; Ming, W.; Ren, L. Thermoresponsive Nanostructures: From Mechano Bactericidal Action to Bacteria Release, ACS Applied Materials & Interfaces 2021, 13, 60865-60877. （IF= 10.383）；

（12）Jiang, R.; Hao, L.; Song, L.; Tian, L.; Fan, Y.; Zhao, J.; Liu, C.; Ming, W.; Ren, L. Lotus-leaf-inspired hierarchical structured surface with non-fouling and mechanical bactericidal performances. Chemical Engineering Journal, 2020, 398, 125609.（IF= 16.744）；

（13）Jiang, R., Yan, S., Tian, L., Xu, S., Xin, Z., Luan, S., Yin J., Ren L., Zhao, J.. A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks. Chinese Journal of Polymer Science, 2018, 36(5), 576-583. (IF = 3.603)；

（14）Jiang, R.#; Xin, Z.; Xu, S.; Shi, H.; Yang, H.; Song, L.; Yan, S.# Luan, S.; Yin, J.; Khan, A.; Li, Y.; Enzyme-mimicking polymer brush-functionalized surface for combating biomaterial-associated infections. Applied Surface Science, 2017, 423, 869-880. (IF = 6.707)。 

三、课题组当前研究方向 

团队目前主要围绕细菌感染、炎症反应、组织损伤、疾病检测等相关疾病和技术开展研究工作，具体研究方向如下：

1.生物医用材料表面生物学性能调控

聚焦于：植/介入类材料表面物理、化学性质与细菌/细胞的互作效应研究；

2.创面伤口愈合策略

聚焦于：兼具杀菌-抗炎-促愈合一体化纳米药物研发；

3.运动损伤康复研究

聚焦于：肌肉损伤快速修复策略研发。

4.智能可穿戴诊疗一体化系统研发

聚焦但不限于：表面增强拉曼散射效应的特性研究，表面增强拉曼光谱结合机器学习实现疾病诊断的应用研究