一、简介

申世立, 博士, 教授, 硕士生导师，山东省青年联合会委员。2009年于山东大学获得学士学位, 2014年于山东大学获博士学位, 2015年进入山东第一医科大学工作。主持国家自然科学基金1项, 山东省自然科学基金2项, 山东第一医科大学学术提升计划1项（骨干，1000万），山东省医药卫生科技发展计划项目1项、泰安市科技局项目2项；指导国家级大学生科技创新课题2项，山东省大学生科技创新课题3项，泰安市大学生科技创新课题1项。以第一或通讯作者在Chemical Science, Chemical Engineering Journal, Sensors and Actuators B, Analytica Chimica Acta, Journal of Materials Chemistry B等杂志发表SCI论文20余篇。授权国家发明专利5项。

二、研究方向

1. 有机光功能材料与生物医学成像

2. 有机合成/药物合成

三、承担的主要科研/教改项目

1. 国家自然科学基金, 21807078, 细胞器靶向跨键能量转移型次氯酸比率荧光探针的合成及其在细胞自噬机制研究中的应用, 主持人。

2. 山东省自然科学基金, ZR2024MB156, 近红外荧光探针在肿瘤精准成像及光疗中的应用, 主持人。

3. 山东省自然科学基金, ZR2016BB35, 跨键能量转移型溶酶体pH比率荧光探针的设计、合成及应用, 主持人。

4. 山东第一医科大学学术提升计划, 2019QL008, 荧光生物传感器的开发及其在疾病相关标志物检测方面的应用, 骨干, 1000万。

5. 泰安市科技发展计划, 2022NS307, 线粒体近红外次氯酸荧光探针的合成及其在细胞自噬机制中研究中的应用, 负责人。

6. 泰安市科技发展计划, 2016GX1018, 溶酶体靶向近红外pH荧光探针的设计合成及细胞内应用,负责人。

7. 山东省医药卫生科技发展计划项目, 2015WS0104, 溶酶体靶向跨键能量转移型pH比率荧光探针的设计、合成及应用, 负责人。

8. 泰山医学院高层次课题培育计划, 2016GCC08, 溶酶体靶向pH比率荧光探针的设计、合成及应用, 负责人。

9. 泰山医学院博士启动基金, 溶酶体靶向荧光探针的合成及细胞内应用, 负责人。

四、发表的主要科研/教改论文

29. Qian Chen, Lin Shen, Jia-Lin Cui, Xiao-Hui Liu, Han-Yang Zou , Xiao-Qun Cao*, Shi-Li Shen*, Xiao-Fan Zhang*, Bifunctional mitochondria-targeting fluorescence probe for in vivo ONOO− and viscosity sensing without signal crosstalk, Sensors & Actuators: B. Chemical 422 (2025) 136686. IF= 8.0

28. Meng-Yu Tang, Qian Chen, Yu Zhang, Haolin Zhang, Xiao-Qun Cao*,Xiao-Fan Zhang*, Shi-Li Shen*, A novel aminopeptidase N triggered near-infrared fluorescence probe for imaging enzyme activity in cells and mice, Sensors & Actuators: B. Chemical 404 (2024) 135290. IF = 8.4

27. Han Dong, Meng-Yu Tang, Shili Shen*, Xiao-Qun Cao* and Xiao-Fan Zhang*, A Small-Molecule Fluorescent Probe for the Detection of Mitochondrial Peroxynitrite, Molecules, 2023, 28, 7976.

26. Xiao-Fan Zhang, Lin Shen, Sheng Wang, Qian Chen, Xiao-Qun Cao*, Shi-Li Shen*, Xiaohua Li*, A new xanthene-based platform for developing NIR fluorogenic probes for in vivo bioimaging, Chemical Engineering Journal 472 (2023) 145065. IF=15.1.

25. Xiaofan Zhang,‡ Shili Shen,‡ Diankai Liu, Xiaohua Li*, Wen Shi, Huimin Ma*,Combination of changeable p-conjugation and hydrophilic groups for developing water-soluble small-molecule NIR-II fluorogenic probes, Chem. Sci., 2023, 14, 2928-2934. IF = 9.969

24. Sheng Wang, Xiao-Fan Zhang, He-Song Wang, Jing Liu*, Shi-Li Shen*, Xiao-Qun Cao*, A highly sensitive NIR fluorescence probe for hypoxia imaging in cells and ulcerative colitis, Talanta, 252 (2023) 123834. IF = 6.556

23.Tian-Ran Wang, Qian Chen, Meng-Yu Tang, Yu Zhang , Shi-Li Shen*, Xiao-Qun Cao*, Visual monitoring of the mitochondrial pH changes during mitophagy with a NIR fluorescent probe and its application in tumor imaging, Spectrochimica Acta Part A 280 (2022) 121496. IF = 4.831

22. Qian Chen, Xiao-Fan Zhang, Teng Wang, Xiao-Qun Cao*, Shi-Li Shen*, A sensitive NIR mitochondria-targeting fluorescence probe for visualizingviscosity in living cells and mice, Analytica Chimica Acta, 1231 (2022) 340443. IF = 6.911

21. He-Song Wang, Xiao-Fan Zhang*, Han Dong, Qian Chen, Xiao-Qun Cao*, Shi-Li Shen*, Activatable near-infrared fluorescent probe triggered by nitroreductase for in vivo ulcerative colitis hypoxia imaging, Analytica Chimica Acta, 1221 (2022) 340107. IF = 6.911

20. Sheng Wang, Yu Zhang, Tian-Ran Wang, Yu-Jun Liu, Shi-Li Shen*, Xiao-Qun Cao*, A near-infrared fluorescent probe based on the hemicyanine skeleton for the detection of hydrogen peroxide in vivo, Spectrochimica Acta Part A 266 (2022) 120435. IF =4.831

19. Yu Zhang, Xiao-Fan Zhang, Qian Chen , Xiao-Qun Cao*, Shi-Li Shen*, A novel near-infrared fluorescence off-on probe for imaging hypoxia and nitroreductase in cells and in vivo. Sensors & Actuators: B. Chemical 353 (2022) 131145. IF =9.221

18. Tian-Ran Wang, Xiao-Fan Zhang, Xiao-Qing Huang, Xiao-Qun Cao, Shi-Li Shen*, Rapid and selective visualization of mitochondrial hypochlorite by a red region water-soluble fluorescence probe, Spectrochimica Acta Part A 247 (2021) 119115. IF =4.831

17. Xiao-Fan Zhang, Tian-Ran Wang, Xiao-Qun Cao, Shi-Li Shen*, A near-infrared rhodamine-based lysosomal pH probe and its application in lysosomal pH rise during heat shockSpectrochimica Acta Part A 227 (2020) 117761. IF =4.831

16. He Meng, Xiao-Qing Huang, Yu Lin, De-Yuan Yang, Yan-Jing Lv, Xiao-Qun Cao*, Gong-Xiao Zhang, Jian Dong, Shi-Li Shen*, A new ratiometric fluorescent probe for sensing lysosomal HOCl based on fluorescence resonance energy transfer strategy, Spectrochimica Acta Part A 223 (2019) 117355. IF =4.831

15. Shi-Li Shen*, Xiao-Qing Huang, Xiao-Hui Lin, Xiao-Qun Cao, A ratiometric fluorescent probe for lysosomal hypochlorous acid based on through-bond energy transfer strategy, Analytica Chimica Acta 1052 (2019) 124. IF =6.911

14. Shi-Li Shen*, Xiao-Qing Huang, Hong-Li Jiang, Xiao-Hui Lin, Xiao-Qun Cao, A rhodamine B-based probe for the detection of HOCl in lysosomes, Analytica Chimica Acta 1046 (2019) 185. IF =6.911

13. Shi-Li Shen*, Xiao-Qing Huang, Yao-Yao Zhang, Yan Zhu, Yan-Qing Ge, Xiao-Qun Cao*, Ratiometric fluorescent probe for the detection of HOCl in lysosomes based on FRET strategy, Sensors and Actuators B, 2018, 263, 252. IF =9.221

12. Shi-Li Shen*, Xiao-Fan Zhang, Yan-Qing Ge, Yan Zhu, Xue-Qin Lang, Xiao-Qun Cao*, A near-infrared lysosomal pH probe based on rhodamine derivative,  Sensors and Actuators B, 2018, 256, 261. IF =9.221

11. Shi-Li Shen, Xiao-Fan Zhang, Yan-Qing Ge, Yan Zhu, Xiao-Qun Cao*, A novel ratiometric fluorescent probe for the detection of HOCl based on FRET strategy, Sensors and Actuators B, 2018, 254, 736. IF =9.221

10. Xiao-Qing Huang, Zhao-Yue Wang, Yan-Jing Lv, Shi-Li Shen*, Yan Zhu, Juan Wang, Yan-Ru Zhang, Jun-Mei Wang, Yan-Qing Ge and Xiao-Qun Cao*, A fluorescent probe for the detection of HOCl in lysosomes, New J. Chem., 2018, 42, 11480. IF =3.925

9. Shi-Li Shen*, Xiao-Fan Zhang, Yan-Qing Ge, Yan Zhu, Xiao-Qun Cao*, RSC Adv., 2017, 7, 55296. IF =4.036

8. Shi-Li Shen, Jun-Ya Ning, Xiao-Fan Zhang, Jun-Ying Miao, Bao-Xiang Zhao*, Through-bond energy transfer-based ratiometric fluorescent probe for the imaging of HOCl in living cells, Sensors and Actuators B: Chemical, 2017, 244, 907. IF =9.221

7. Shi-Li Shen, Xuan Zhao, Xiao-Fan Zhang, Xuan-Li Liu, Hao Wang, Yi-Ying Dai, Jun-Ying Miao and Bao-Xiang Zhao*, A mitochondria-targeted ratiometric fluorescent probe for hypochlorite and its applications in bioimaging, Journal of Materials Chemistry B, 2017, 5, 289. IF =7.571

6.Shi-Li Shen, Xin-Peng Chen, Xiao-Fan Zhang, Jun-Ying Miao*, Bao-Xiang Zhao*，A rhodamine B-based lysosomal pH probe, Journal of Materials Chemistry B, 2015, 3, 919. IF =7.571

5. Shi-Li Shen, Xiao-Fan Zhang, Su-Yun Bai, Jun-Ying Miao*, Bao-Xiang Zhao*，A ratiometric lysosomal pH probe based on thecoumarin–rhodamine FRET systemRSC Advances, 2015, 5, 13341. IF =4.036

4. Wei-Yong Liu#, Shi-Li Shen#, Hai-Ying Li, Jun-Ying Miao*, Bao-Xiang Zhao*, Fluorescence turn-on chemodosimeter for rapid detection of mercury (II) ions in aqueous solution and blood from mice with toxicosis, Analytica Chimica Acta, 2013, 791, 65. IF =6.911

3. Shi-Li Shen, Jin-Hui Shao, Jin-Ting Liu, Jun-Ying Miao*, Bao-Xiang Zhao*, Novel chiral ferrocenylpyrazolo[1,5-a][1,4]diazepin-4-one derivatives-Synthesis, characterization and inhibition against lung cancer cells European Journal of Medicinal Chemistry, 2013, 63, 256. IF =7.088

2. Shi-Li Shen, Liang-Wen Zheng, Sheng-Qing Wang, Yan-Ru Zhang, Yuan Zhang, Ying-Rui Liu, and Bao-Xiang Zhao*, ARKIVOC, 2013, (iv) 44-56.

1. Shi-Li Shen, Jian Zhu, Meng Li, Bao-Xiang Zhao*, Jun-Ying Miao*, Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells，European Journal of Medicinal Chemistry, 2012, 54, 287. IF =7.088

五、授权的主要专利

1. 一种应用于线粒体内次氯酸检测的比率荧光探针的制备及应用, 发明专利，ZL20171 11186915

2. 一种应用于溶酶体内HOCl检测的荧光探针的制备及应用, 发明专利，ZL 2018100377970

3. 一种用于检测硝基还原酶的近红外荧光探针及应用，发明专利，ZL 2021113405171

4. 近红外荧光探针及其制备方法与应用，国际发明专利，2032434

5. 一种罗丹明类近红外荧光探针以及制备方法和应用, 国际发明专利，2032012